Recherchiere Firmenbekanntmachungen und finanzielle Kennzahlen
UK-Förderung (349.114 £): Rolle der Wnk1-Kinase bei der Adhäsion und Migration von T-Zellen Ukri01.01.2014 Forschung und Innovation im Vereinigten Königreich, Großbritannien
Auf einen Blick
Text
Rolle der Wnk1-Kinase bei der Adhäsion und Migration von T-Zellen
| Zusammenfassung | White blood cells are a key part of the body's immune system, playing a critical role in combating infections by viruses, bacteria and other pathogens. Our research is focussed on a type white blood cell called a T cell, which can detect the presence of an infectious agent such as a virus inside other cells. We are interested in understanding the mechanism by which a T cell recognises whether another cell contains an infectious agent within it. As part of this process, the T cell and the infected cell have to adhere tightly to each other and we are studying this process of adhesion. In recent work we have identified that a protein called Wnk1 plays an important role in regulating T cell adhesion, and in the research we are now proposing, we will extend this work by examining how the T cells function when they lack the protein, and whether this makes them defective in contributing to normal immune responses. We suspect that Wnk1 may also control how the T cells migrate through the body. Normal T cells are continuously on the move, trafficking between the blood and lymph nodes and the spleen. This continuous movement is a vital feature of the T cells as it allows them to patrol the body looking for signs of infection. We will investigate this potential function of the Wnk1 protein in controlling T cell migration. We suspect that Wnk1 functions as a signalling protein, transmitting signals from the surface of the cell to adhesion molecules. We will investigate this hypothesis further by looking for other proteins to which Wnk1 transmits a signal. Overall our aim is to understand how Wnk1 controls T cell adhesion and migration. Such knowledge will reveal new opportunities for the design of rational drugs that could modulate the function of T cells and thereby the whole immune system. |
| Kategorie | Research Grant |
| Referenz | BB/L00805X/1 |
| Status | Closed |
| Laufzeit von | 01.01.2014 |
| Laufzeit bis | 31.12.2016 |
| Fördersumme | 349.114,00 £ |
| Quelle | https://gtr.ukri.org/projects?ref=BB%2FL00805X%2F1 |
Beteiligte Organisationen
| The Francis Crick Institute | |
| University of Bern |
Die Bekanntmachung bezieht sich auf einen vergangenen Zeitpunkt, und spiegelt nicht notwendigerweise den heutigen Stand wider. Der aktuelle Stand wird auf folgender Seite wiedergegeben: The Francis Crick Institute Ltd., London, Großbritannien.
Die Visualisierungen zu "The Francis Crick Institute - UK-Förderung (349.114 £): Rolle der Wnk1-Kinase bei der Adhäsion und Migration von T-Zellen"
werden von
North Data
zur Weiterverwendung unter einer
Creative Commons Lizenz
zur Verfügung gestellt.
